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year 27, Issue 2 (ICOP & ICPET 2021 2021)
ICOP & ICPET _ INPC _ ICOFS 2021, 27(2): 33-35 |
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Shirkavand A, Mohajerani E, Ataie Fashtami L, Farivar S, Ghazimoradi M H. Ddetermination of optical refractive index and electrical permittivity for differential detection of healthy and cancerous human cells by reflectance spectroscopy. ICOP & ICPET _ INPC _ ICOFS 2021; 27 (2) :33-35
URL: http://opsi.ir/article-1-2299-en.html
URL: http://opsi.ir/article-1-2299-en.html
Afshan Shirkavand1 
, Ezeddin Mohajerani *2 , Leila Ataie Fashtami3 , Shirin Farivar4 , Mohammad Hosein Ghazimoradi4
, Ezeddin Mohajerani *2 , Leila Ataie Fashtami3 , Shirin Farivar4 , Mohammad Hosein Ghazimoradi4
1- Laser and Plasma Institute, Shahid Beheshti University, Tehran, Iran, Laser Medicine group, MLRC, ACECR, Tehran, Iran
2- Laser Medicine group, MLRC, ACECR, Tehran, Iran
3- Department of Regenerative Medicine, Royan Institute for Stem cell biology & Technology, ACECR, Tehran, Iran
4- Genetics and Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
2- Laser Medicine group, MLRC, ACECR, Tehran, Iran
3- Department of Regenerative Medicine, Royan Institute for Stem cell biology & Technology, ACECR, Tehran, Iran
4- Genetics and Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
Abstract: (975 Views)
Due to the interest towards the development of personalized medicine, accurate differential diagnosis is crucial for optimizing cancer therapy efficiency. In the last decade, optical methods like, using diffuse reflectance spectroscopy (DRS), has been used as a non‐destructive technique for optical characterization of biological tissue and cell samples. Any alteration in cells causes a figure print effect. The aim of this study is to develop a computerized program for extraction of complex refractive index and corresponding electric permittivity from the Vis-NIR reflectance spectra of sample cells as a key biophysical parameter seems to reflect cells’ changes which were tested for discrimination melanoma cancer from normal cells of the skin.
Keywords: Reflectance spectroscopy, Refractive index, Electric permittivity, Human skin melanoma, Differential diagnosis
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