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Naeima H, Bahreini M, Tavassoli S H. Three dimensional Mapping of Pharmaceutical Tablet Content Uniformity by Laser Induced Breakdown Spectroscopy (LIBS). ICOP & ICPET _ INPC _ ICOFS 2014; 20 :909-912
URL: http://opsi.ir/article-1-366-en.html
URL: http://opsi.ir/article-1-366-en.html
Abstract: (5044 Views)
This paper assess the ability of laser-induced breakdown spectroscopy to determine the distribution of pharmaceutical components in solid dosage forms. Three dimensional mapping shows elemental distribution across the surface and throughout the core of the sample. In this experiment, lithium carbonate tablets are used and surface distribution and depth profile of components have been obtained. Results show that concentration of calcium decreases and lithium increases by going from the surface toward the depth of the tablet.
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