Association Mission
The mission of the association is to advance the creation, communication and application of knowledge to benefit society and improve people's lives.
Legal Members
Membership
Contact Us
year 28, Issue 2 (ICOP & ICPET 2022 2022)
ICOP & ICPET _ INPC _ ICOFS 2022, 28(2): 558-561 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
nasrabadi B, Zibaii M I, Hosseini S M. study and modeling of the temperature effect caused by light radiation on brain tissue and response of neurons in optogenetic control. ICOP & ICPET _ INPC _ ICOFS 2022; 28 (2) :558-561
URL: http://opsi.ir/article-1-2610-en.html
URL: http://opsi.ir/article-1-2610-en.html
1- Shahid Beheshti University
Abstract: (847 Views)
Optogenetics is an advanced optical tool in neuroscience research. However, light stimulation in optogenetic experiments may also affect neural function not only by directly stimulating light-sensitive channels, but also by generating heat. In this paper, the effect of increasing temperature of the brain tissue was studied with light stimulation. To investigate the effect of temperature on spike neuron, Hodgkin-Huxley model and the hippocampal pyramidal cell model have been used. The modeling results show that irradiation of brain tissue by pulsed laser with a frequency of 40 Hz, duty cycle of 90% and wavelength of 593 nm at a distance of 10 μm from the fiber, for 60 seconds with a power of 1 and 40 mW leads to temperature change to 39 ° C. The results show intensity of the laser decreases to zero at a distance of 1 mm from tip of fiber, which is absorbed by the tissue and causes a temperature rise of 2 ° C that can increase the spike rate of neurons by 16.6%.
Type of Study: Experimental |
Subject:
Special
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
