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Volume 25 - ICOP & ICPET 2019
ICOP & ICPET _ INPC _ ICOFS 2019, 25 - ICOP & ICPET 2019: 229-232 |
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Baloochi A, Bigdeli M R, Dargahi L, Nazari S M, Ghorbani A, Chavoshinezhad S, et al . Prevention of Stroke in Rats Using Optogenetic Technique . ICOP & ICPET _ INPC _ ICOFS 2019; 25 :229-232
URL: http://opsi.ir/article-1-1905-en.html
URL: http://opsi.ir/article-1-1905-en.html
Andisheh Baloochi *1 
, Mohammad reza Bigdeli1 , Layla Dargahi1 , Seyed mirhossein Nazari1 , Ahmad Ghorbani1 , Sara Chavoshinezhad1 , Hamid Latifi1 , Mohammad esmaeil Zibaei1
, Mohammad reza Bigdeli1 , Layla Dargahi1 , Seyed mirhossein Nazari1 , Ahmad Ghorbani1 , Sara Chavoshinezhad1 , Hamid Latifi1 , Mohammad esmaeil Zibaei1
1- Shahid Beheshti University, Tehran
Abstract: (2199 Views)
Brain Stroke is one of the most dangerous diseases of the nervous system. This complication is the second leading cause of death in the world. Different methods have been suggested for the treatment of this disease. In this study, we study the preventive effects of optogenetics stimulation in the animal model of ischemic stroke. For this purpose, by injection of Channelrhodopsin (CHR) opsin, implantation of optical fibers and laser blue light irradiation in the rat striatum, glutamateuric neurons were stimulated. Obtained results show optical stimulation leads to increasing of neurogenesis in the SVZ region and thereby reducing the infract volume after induction of ischemic stroke.
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