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Karami F, Zibaii M I, Noraepour Z, Latifi H. Design and simulation of tip tapered fiber optic for controlling illumination of brain tissue in optogenetics applications. ICOP & ICPET _ INPC _ ICOFS 2018; 24 :849-852
URL: http://opsi.ir/article-1-1438-en.html
URL: http://opsi.ir/article-1-1438-en.html
1- Laser and Plasma Research Institute, Shahid Beheshti University
Abstract: (2918 Views)
One of the challenges in the optogenetics technique is light delivery to various points in brain tissue with optical devices. In this paper, two optical probes based on tapered tip fiber optic (TTF) designed and simulated for controlling of volumetric scan and spatial illumination of brain tissue in optogenetic applications. These TTFs can propagate optical rays to certain several points of the tissue and have minimally invasive. For controlling illumination of the different layers of the brain tissue, a TTF with several windows on its surface is designed. Simulation and analytical analysis show that each window only passes a particular group of fiber modes. By simulation, we can show power rate for different guiding modes in optical fiber and out-coupling powers from two windows. The results show that the window near the tip can deliver most of the modes optical power to the tissue. So, the rays should couple to the fiber by lowest angles. As a result, we can find the best coupling angle for other windows by this analysis.
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