From ancient time, silk was known as a luxury fabric, however, its outstanding mechanical and optical properties have attracted the scientists in recent years, which led to numerous extracted products like microspheres, hydrogels, tubes, etc. In this paper, first we explained our experimental method in extracting the biocompatible silk solution in several steps and then the silk thin film was suggested as a plasmonic substrate. Circular dichroism (CD) response of silk solution was recorded which has shown a considerable CD signal with high sensitivity to right- and left-hand circularly-polarized incident light. This outstanding property has a significant potential in CD plasmonic sensing. Regarding its optical properties, the silk film was patterned using soft lithography technique and a thin layer of gold was sputtered on its top surface. Our 2D plasmonic sensor with potential medical application like neuroplasmonic was fabricated.

Keywords: Silk, Thin film, Plasmonic substrate, Sensor.

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