The use of orbital angular momentum (OAM) of light in optical communication systems has led to an increase in data transmission capacity. Circular photonic crystal fibers (C-PCFs) with an air-core in the center are good candidates for guiding OAM of light. In this paper, a special design of C-PCFs is simulated in Comsol software and the controlling of OAM modes is proposed based on optofluidic infiltrated C-PCF while keeping the geometrical parameters fixed. The results show the OAM modes can be well controlled in optofluidic-infiltrated C-PCFs over the wavelength range of 1.25-2.0 μm.