ptical biosensors based on surface plasmon resonance (SPR) are an important component in biophotonic  field.These biosensor are applicable for investigation type of disease  In this paper, an optical biosensor SPR-based  Photonic Crystal Fiber is designed that determine four molecules  water, Blood Plasma, YD-10B, Hemoglobin, which have unique refractive index, at a wavelength of 500 to 750 nm . and Enhancement of  refractive index optical biosensor is designed using a structure consisting of a gold layer. Our results also show that the maximum relative sensitivity for this biosensor is calculated 266 nm/RIU for layer of gold with a thickness of 40 nm.

Keywords: Surface Plasmon Resonance, Photonic Crystal Fiber, Biosensor, relative Sensitivity

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