fa Photo Thermal Lens Spectrometry of Gold Nanoparticles Interaction with Thiol Containing Biomolecules تخصصی Special پژوهشي Research Sensitivity, thermooptical properties and low sample consumption are major properties that highlighted Photo Thermal Lens microscopy (PTLM) for detection of biomolecules. In this work, we utilized a coaxial photo thermal lens microscope equipped with a continuous-wave excitation (wavelength, 532 nm) and probe (wavelength, 652 nm) laser beam to investigate the interactions of gold nanoparticles with Captopril as an example of thiol containing biomolecules. GNPs due to their surface plasmon resonance (SPR) possess the absorption in visible range. Following the addition of trace Captopril, the color of gold colloid solution gradually changes. As a consequence the Photothermal lens signal enhanced. The changes of PTLM signal were found to be proportional to the concentration of Captopril over the range of 0.1–2 mgL−1. Sensitivity, thermooptical properties and low sample consumption are major properties that highlighted Photo Thermal Lens microscopy (PTLM) for detection of biomolecules. In this work, we utilized a coaxial photo thermal lens microscope equipped with a continuous-wave excitation (wavelength, 532 nm) and probe (wavelength, 652 nm) laser beam to investigate the interactions of gold nanoparticles with Captopril as an example of thiol containing biomolecules. GNPs due to their surface plasmon resonance (SPR) possess the absorption in visible range. Following the addition of trace Captopril, the color of gold colloid solution gradually changes. As a consequence the Photothermal lens signal enhanced. The changes of PTLM signal were found to be proportional to the concentration of Captopril over the range of 0.1–2 mgL−1. biomolecules, gold nanoparticles, Photothermal lens microscopy, Plasmonic biomolecules, gold nanoparticles, Photothermal lens microscopy, Plasmonic 1603 1606 http://opsi.ir/browse.php?a_code=A-10-1-774&slc_lang=fa&sid=1 Nader Shokoufi Nader Shokoufi shokoufi@ccerci.ac.ir 10031947532846003715 10031947532846003715 Yes Chemistry & Chemical Engineering Research Center of Iran (CCERCI) Chemistry & Chemical Engineering Research Center of Iran (CCERCI) Atefeh Abbasi Ahd Atefeh Abbasi Ahd atefeh.abbasiahd@gmail.com 10031947532846003716 10031947532846003716 No Chemistry & Chemical Engineering Research Center of Iran (CCERCI) Chemistry & Chemical Engineering Research Center of Iran (CCERCI) Kazem Kargosha Kazem Kargosha k.kargosha@ccerci.ac.ir 10031947532846003717 10031947532846003717 No Chemistry & Chemical Engineering Research Center of Iran (CCERCI) Chemistry & Chemical Engineering Research Center of Iran (CCERCI)