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Volume 26 - ICOP & ICPET 2020
ICOP & ICPET _ INPC _ ICOFS 2020, 26 - ICOP & ICPET 2020: 969-972 |
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Arefnia F, Hosseini S M, Karimi Tar H, Asadollahi Fana A, Ghaneie F, Zibaii M I et al . Modeling of Brain Tissue Refractive Index Changing by Ultrasound for Directing Light in Optogenetic Stimulation. ICOP & ICPET _ INPC _ ICOFS 2020; 26 :969-972
URL: http://opsi.ir/article-1-2170-en.html
URL: http://opsi.ir/article-1-2170-en.html
Fatemeh Arefnia1 , Seyedeh Mahshad Hosseini1 , Hedieh Karimi Tar1 , Amir Asadollahi Fana1 , Firoozeh Ghaneie1 , Mohammad Ismail Zibaii * 1, Hamid Latifi1
1- Shahid Beheshti University
Abstract: (1582 Views)
Understanding and controlling the function of the brain is a challenge in modern neuroscience. Optogenetics as a new tool in neuroscience provides an effective way of manipulating a specific cell type by light stimulating microbial opsin expressed cells on a timescale of milliseconds. Typically, light delivery into targeting areas is achieved using optical fibers coupled to external laser diodes or light emitting diodes (LEDs). The optical fibers are inserted into the skull to stimulate the neurons, which is impractical for daily use. Also, scattering processes limit the depth to which externally focused light can penetrate tissue. In this paper we present that ultrasound can be used to define and steer the trajectory of light within scattering media by exploiting local pressure differences created by acoustic waves that result in refractive index contrasts. We demonstrate the application of this technology can be used for confining light through mouse brain tissue for optogenetics applications.
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